These words link opposing ideas, but the forms following them and the punctuation are different.
In sentences using although, even though, in spite of and despite, the clauses can change position.
Clause 1*
|
Clause 2* | |
Although Even though |
he is intelligent, |
he can't get a job.
|
In spite of Despite |
his intelligence, being intelligent, |
*Clauses 1 and 2 can change position.